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Target intelligence / Profile preview
Parasite Serotonergic G-protein Coupled Receptor (5-HT GPCR (Parasite))
- Target
- 5-HT GPCR (Parasite)
- Molecular classification
- G protein-coupled receptor, Serotonin receptor, 5-HT1-like receptor
01
Overview
Parasite serotonergic GPCRs, particularly 5-HT1-like receptors, are involved in the regulation of motility, development, reproduction, and neuromuscular function in helminths. These receptors offer a potential therapeutic target because of their unique pharmacology compared to mammalian counterparts. Targeting these receptors could impair parasite viability without affecting host tissues.
- Other names
- Parasite 5-HT1 receptorParasite Serotonin ReceptorCestode 5-HT GPCRHelminth Serotonin Receptor
02
Mechanism of action
Disruption of neuromuscular function and motility via GPCR modulation
03
Biological functions
Neuromuscular functionMotility controlSensory input integrationReproduction regulationSignal transduction
04
Disease associations
Parasitic infectionNeurocysticercosis
05
Safety considerations
Selectivity for parasite receptors to avoid affecting host serotonin pathwaysPotential for drug resistance
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