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Parasite-Specific GABA-Chloride Channel (GABA-Cl Channel (Parasite))
- Target
- GABA-Cl Channel (Parasite)
- Molecular classification
- Ligand-gated ion channel, Ion channel, Receptor
01
Overview
The parasite-specific GABA-chloride channel is a ligand-gated ion channel activated by GABA, leading to chloride influx and neuronal/muscle cell inhibition. It is found in nematodes and flatworms and is a target for anthelmintic drugs. It differs from mammalian GABA receptors, providing a basis for selective drug targeting.
- Other names
- Parasite GABA receptorHelminth GABA-gated chloride channelNematode GABA receptorFlatworm GABA receptor
02
Mechanism of action
Agonist binding leads to increased chloride ion influx, causing hyperpolarization and paralysis.
03
Biological functions
Inhibitory neurotransmissionNeuromuscular regulationControl of locomotionPharyngeal functionSensory processing
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects in hostDevelopment of drug resistance in parasites
06
Interacting drugs
Avermectins
1 more in the full profile.
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