Paraspeckle component 1 (PSPC1)

Paraspeckle component 1 (PSPC1) is a multifunctional RNA-binding protein and the first-discovered core structural protein of paraspeckles, which are subnuclear, membrane-less organelles found adjacent to splicing speckles in transcriptionally active cells[1][2][3][4]. PSPC1 contains two N-terminal RNA recognition motifs (RRM1, RRM2), a NONA/paraspeckle domain (NOPS), and a C-terminal coiled-coil domain essential for paraspeckle assembly and function[1][4]. PSPC1 participates in the regulation of gene expression, DNA damage repair, mRNA modification, cell fate determination, differentiation, and immune responses; it is overexpressed or dysregulated in various cancers, where it facilitates metastasis and therapy resistance, making it a candidate biomarker and therapeutic target[1][2][3][4].

Other names

Paraspeckle protein 1PSP1FLJ10955Paraspeckle component 1PSPC1

For drugs targeting pathways modulated by PSPC1: Inhibition of PSPC1 enhances DNA damage and causes mitotic catastrophe in cancer cells treated with PARP inhibitors. PSPC1 suppression may reverse endocrine therapy resistance in hormone-positive cancers.