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Parathion Hydrolase
- Molecular classification
- Enzyme, Hydrolase, Organophosphorus hydrolase, Metalloenzyme
01
Overview
Parathion hydrolase is an enzyme that catalyzes the hydrolysis of parathion, a toxic organophosphate insecticide, converting it into less harmful compounds. It plays a crucial role in the biodegradation and detoxification of organophosphates, making it significant for environmental and bioremediation applications. Found in various bacterial species, its activity is dependent on metal ions at the active site. While it exhibits broad substrate specificity towards organophosphates, it doesn't function as a general esterase or protease.
02
Mechanism of action
Hydrolyzes parathion and related organophosphates by breaking phosphoester bonds, converting them into less toxic compounds.
03
Biological functions
CatalysisHydrolysis of organophosphatesBiodegradationDetoxification
04
Disease associations
Pesticide poisoning
05
Safety considerations
Potential inhibition by sulfhydryl reagents and certain metal ions.Variability in activity and substrate specificity among different isoforms.
06
Interacting drugs
Parathion
1 more in the full profile.
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