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Target intelligence / Profile preview
Parathyroid hormone/Parathyroid hormone-related peptide receptor type 1 (PTH1R)
- Target
- PTH1R
- Molecular classification
- G protein-coupled receptor, GPCR, Class B GPCR, Secretin family GPCR
01
Overview
The parathyroid hormone/parathyroid hormone-related peptide receptor type 1 (PTH1R) is a Class B GPCR that serves as the primary receptor for both parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It plays a critical role in regulating skeletal development, bone turnover, and mineral ion homeostasis, particularly calcium and phosphate balance. PTH1R is highly expressed in bone, kidney, and cartilage. Ligand binding activates G proteins, stimulating adenylyl cyclase and increasing intracellular cAMP, or activating the phospholipase C pathway and mobilizing intracellular calcium. Mutations in PTH1R are associated with several skeletal disorders, and it is a therapeutic target for conditions like osteoporosis and hypoparathyroidism.
- Other names
- Parathyroid hormone/parathyroid hormone-related peptide receptorParathyroid hormone 1 receptorPTH/PTHrP type I receptorPTH/PTHr receptor
02
Mechanism of action
Agonists stimulate adenylyl cyclase/cAMP pathway or phospholipase C/Ca2+ pathway to regulate bone metabolism.
03
Biological functions
Signal transductionCalcium homeostasisPhosphate homeostasisSkeletal developmentBone turnover
04
Disease associations
Jansen's metaphyseal chondrodysplasiaBlomstrand chondrodysplasiaEnchondromatosisPrimary failure of tooth eruptionOsteoporosisHypoparathyroidism
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