Parathyroid hormone 1 receptor (PTH1R) (PTH1R)

The Parathyroid hormone 1 receptor (PTH1R) is a Class B G protein-coupled receptor that plays a central role in calcium and phosphate homeostasis by mediating the actions of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) (UniProt, 2024). It is highly expressed in osteoblasts and renal tubular cells, where its activation triggers signaling through the Gs/adenylate cyclase and Gq/phospholipase C pathways (PubMed, 2023). In bone, intermittent activation of PTH1R promotes osteoblast differentiation and bone formation, making it a key target for anabolic osteoporosis therapies (NIH, 2024). Conversely, continuous activation leads to increased bone resorption via the RANKL pathway. Mutations in the PTH1R gene are linked to rare genetic disorders like Jansen's metaphyseal chondrodysplasia and Blomstrand chondrodysplasia (StatPearls, 2024). Clinical agents such as teriparatide and abaloparatide act as PTH1R agonists to increase bone mass in patients with high fracture risk (PubChem, 2024). Although the query specifies "mouse Pth1r mRNA," the primary therapeutic focus is the human receptor protein, with mouse mRNA levels often serving as a research biomarker for receptor expression in preclinical studies (PubMed, 2022).

Other names

Pth1rPTH/PTHrP receptorParathyroid hormone receptor 1PTHR1

Agonist of the parathyroid hormone 1 receptor, stimulating adenylate cyclase and phospholipase C pathways to regulate bone formation and mineral balance.