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Target intelligence / Profile preview
Parathyroid Hormone 2 Receptor
- Molecular classification
- G protein-coupled receptor, GPCR, Class B GPCR, Type II GPCR, Receptor
01
Overview
The parathyroid hormone 2 receptor (PTH2R) is a member of the class B (type II) G protein-coupled receptor (GPCR) family. The primary endogenous ligand for PTH2R is tuberoinfundibular peptide of 39 residues (TIP39). Human PTH can activate human PTH2R but not rodent orthologs. PTH2R is highly expressed in specific regions of the brain and in the pancreas. It is involved in neuroendocrine regulation, modulates stress response, nociception, calcium transport, and wound healing. It is coupled primarily to Gs proteins, activating adenylyl cyclase, which increases cAMP.
- Other names
- PTH2RParathyroid hormone 2 receptorPTHR2
02
Mechanism of action
Agonist: Activates adenylyl cyclase, increases cAMP. Antagonist: Blocks receptor activation by TIP39.
03
Biological functions
Signal transductionNeuroendocrine regulationModulates stress responseNociceptionCalcium transportWound healingcAMP signalingAdenylyl cyclase activation
04
Interacting drugs
TIP39
2 more in the full profile.
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