Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Parathyroid hormone receptor (PTH1R)
- Target
- PTH1R
- Molecular classification
- G protein-coupled receptor, Class B G protein-coupled receptor, Receptor
01
Overview
The parathyroid hormone receptor 1 (PTH1R) is a class B G protein-coupled receptor that acts as a central regulator of calcium and phosphate homeostasis. It is activated by parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP), and primarily signals through Gs proteins to activate adenylyl cyclase and cAMP production. It is highly expressed in bone and kidney, where it plays critical roles in bone resorption and mineral ion reabsorption/excretion. Defects in PTH1R are associated with several skeletal disorders.
- Other names
- PTHRPTH/PTHrP type I receptor
02
Mechanism of action
Agonist or antagonist binding modulates cAMP and IP3/Ca2+ signaling pathways.
03
Biological functions
Signal transductionCalcium ion homeostasisPhosphate homeostasisSkeletal developmentBone resorptionRegulation of mineral ion homeostasis
04
Disease associations
Jansen's metaphyseal chondrodysplasiaBlomstrand chondrodysplasiaEnchondromatosisPrimary failure of tooth eruptionOsteoporosisHypoparathyroidism
Beyond the preview
Go deeper on Parathyroid hormone receptor (PTH1R).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Parathyroid hormone receptor (PTH1R).