Parathyroid hormone receptor type 1 (PTH1R)

Parathyroid hormone receptor type 1 (PTH1R) is a class B G protein-coupled receptor (GPCR) that mediates the effects of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP), playing a central role in calcium and phosphate homeostasis and bone metabolism[1][4][5][7][9]. PTH1R is highly expressed in bone and kidney cells, and when activated by PTH (or PTH analog drugs), stimulates signaling pathways that promote bone remodeling, increase serum calcium, and influence vitamin D metabolism. Therapeutically, PTH1R agonists (teriparatide, abaloparatide, and long-acting PTH analogs) are used in treating osteoporosis and hypoparathyroidism, with notable safety concerns that restrict duration of use due to risks of hypercalcemia and osteosarcoma[2][4][8][9]. The "Parathyroid hormone pathway" comprises the hormonal signaling (primarily via PTH1R), the downstream effects on bone, kidney, and gut, and is not itself a direct druggable entity, but its receptor PTH1R is the canonical pharmacological target.

Other names

Parathyroid hormone receptorPTH receptorType 1 parathyroid hormone receptorPTHR1

Agonism of PTH1R to stimulate bone formation (anabolic effect); Agonism/activation causing increased serum calcium via bone resorption, renal and intestinal effects