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Parathyroid Hormone-related Protein (None)
- Target
- None
- Molecular classification
- Hormone, Growth factor, Cytokine
01
Overview
Parathyroid hormone-related protein (PTHrP) is a proteinaceous hormone and a member of the parathyroid hormone family. It is secreted by mesenchymal stem cells and, in certain pathological conditions, by cancer cells. PTHrP primarily acts via the parathyroid hormone type 1 receptor (PTH1R), regulating bone development, calcium homeostasis, smooth muscle relaxation, and cellular proliferation/differentiation. Overproduction can occur in malignancies leading to humoral hypercalcemia of malignancy. Blood tests measuring circulating levels are used primarily when evaluating unexplained hypercalcemia suspected to be related to malignancy.
- Other names
- PTHrPPTHLH
02
Mechanism of action
N/A
03
Biological functions
Bone developmentCalcium homeostasisSmooth muscle relaxationCell proliferationCell differentiationRegulation of apoptosisPlacental calcium transfer
04
Disease associations
Humoral hypercalcemia of malignancyOsteoporosisAbnormal tooth eruptionDevelopmental defectsCancer
05
Safety considerations
Excessive production can lead to hypercalcemia
06
Biomarkers
Elevated PTHrP levels in hypercalcemia of malignancy
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