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Target intelligence / Profile preview
Parathyroid Hormone Replacement (None)
- Target
- None
- Molecular classification
- Hormone, Peptide, Recombinant Protein
01
Overview
Parathyroid hormone (PTH) replacement refers to the therapeutic use of recombinant or synthetic forms of PTH to treat conditions where endogenous PTH is deficient, most notably hypoparathyroidism. It aims to restore more physiological regulation of serum calcium, reduce complications associated with standard therapy, and improve quality of life.
- Other names
- rhPTH(1-84)Recombinant human PTH(1-84)rhPTH(1-34)Recombinant human PTH(1-34)TeriparatideNatpara
02
Mechanism of action
Mimics endogenous PTH action at target tissues by binding to and activating the parathyroid hormone/parathyroid hormone-related protein receptor type 1 (PTHR1)
03
Biological functions
Calcium homeostasis regulationPhosphate homeostasis regulationBone resorption stimulationRenal calcium reabsorption enhancementVitamin D activation stimulation
04
Disease associations
Hypoparathyroidism
05
Safety considerations
HypercalcemiaHypocalcemiaInjection site reactionsHeadacheNauseaArthralgiaParesthesia
06
Interacting drugs
rhPTH(1-84)
4 more in the full profile.
07
Biomarkers
Serum calcium levelsUrinary calcium excretionSerum phosphate levelsBone turnover markers
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