Target intelligence / Profile preview

PARD6G antisense RNA 1 (PARD6G-AS1)

Target: PARD6G-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA, Other

Overview

PARD6G antisense RNA 1 (PARD6G-AS1) is a long non-coding RNA transcribed antisense to the PARD6G gene. It does not encode a protein and is involved in the regulation of gene expression primarily through epigenetic mechanisms such as imprinting and methylation. PARD6G-AS1 can act as a sponge for microRNAs, thereby modulating the activity of microRNAs and impacting target gene expression[2]. Its promoter region is differentially methylated in a parent-of-origin-dependent (maternal) manner, with hypomethylation implicated in several imprinting disorders and certain hematopoietic cancers[3]. PARD6G-AS1 is expressed biallelically across multiple human tissues and is not subject to classical monoallelic imprinting-based silencing[3]. There are currently no known drugs that directly target PARD6G-AS1, nor are there established biomarkers or targeted therapeutic safety concerns reported in the literature[5].

Other names: PARD6G antisense RNA 1 (non-protein coding)PARD6G-AS1

Biological functions

Regulation of gene expressionMicroRNA sponge activityEpigenetic imprinting and methylation regulationOther

Disease associations

Cancer (imprinted methylation anomalies reported in certain cancers[3])Imprinting disorders (e.g., Beckwith-Wiedemann syndrome, transient neonatal diabetes, pseudohypoparathyroidism[3])Other

Beyond the preview

Go deeper on PARD6G antisense RNA 1 (PARD6G-AS1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on PARD6G antisense RNA 1 (PARD6G-AS1).

Explore the full profile