Parenchymal and stromal tissue cells in injured organs

Parenchymal and stromal tissue cells in injured organs refer to the functional and structural cell populations that are the focus of regenerative and protective therapies. Parenchymal cells are the functional components of an organ, such as hepatocytes in the liver or nephrons in the kidney, while stromal cells provide the structural framework and support (StatPearls, 2023). This specific terminology is frequently used in the development of Hepatocyte Growth Factor (HGF) mimetics, such as ANG-3777, which aim to activate the c-Met receptor on these cells to stimulate repair and prevent cell death following acute injury (Angion Biomedica, 2021). Because this term describes a collection of cell types rather than a specific molecule, it is not a standard molecular target but rather a physiological site of action. Its clinical relevance is highest in conditions like acute kidney injury (AKI) and acute lung injury, where preserving the integrity of both functional and supporting cells is critical for recovery (PubMed, 2020). The activation of signaling pathways in these cells can lead to improved organ function and reduced long-term damage. However, the broad activation of these cells also presents challenges, such as the potential for promoting unwanted cell growth or fibrosis. Overall, this 'target' represents a holistic approach to organ repair by addressing the entire tissue microenvironment.

Other names

Parenchymal cellsStromal cellsOrgan functional and structural cellsTissue-resident cells in injury

Activation of the c-Met receptor (Hepatocyte Growth Factor receptor) on these cells to promote survival and regeneration (Angion Biomedica, 2021).