Particulate Guanylate Cyclase Receptor A (NPR-A)

NPR-A (Natriuretic Peptide Receptor A), also known as Guanylyl Cyclase-A (GC-A), is a membrane-bound receptor with intrinsic guanylyl cyclase activity. It is the primary receptor for atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), playing a crucial role in cardiovascular homeostasis by regulating blood volume and blood pressure through vasodilation, natriuresis, and diuresis. Upon ligand binding, NPR-A dimerizes and catalyzes the conversion of GTP to cGMP, initiating a signaling cascade that affects smooth muscle relaxation, renal function, and cell proliferation.

Other names

Natriuretic Peptide Receptor ANPRAGuanylyl Cyclase-AGC-A

Ligand binding (ANP, BNP) stimulates guanylyl cyclase activity, increasing intracellular cGMP levels and activating downstream effectors (PKGs, PDEs, CNGs) to mediate vasodilation, natriuresis, and diuresis.