Partner and localizer of BRCA2 (PALB2)

Partner and localizer of BRCA2 (PALB2) is a tumor suppressor protein essential for homologous recombination-mediated repair of DNA double-strand breaks. It acts as a scaffold, recruiting and stabilizing BRCA2 and RAD51 at sites of DNA damage, and directly interacts with BRCA1 to promote the assembly of DNA repair complexes. PALB2 helps to maintain genomic integrity, prevent accumulation of DNA damage, and suppress tumorigenesis. Inherited monoallelic mutations confer a significantly increased risk of breast, pancreatic, and ovarian cancers, whereas biallelic mutations cause Fanconi anemia subtype N, characterized by early-onset cancer predisposition and hematologic disorders. PALB2-deficient cancers may be sensitive to synthetic lethal approaches such as PARP inhibition[1][3][4][5][6][7].

Other names

FANCNFanconi anemia, complementation group NPNCA3FLJ21816BROVCA5partner and localizer of BRCA2mutant partner and localizer of BRCA2

Synthetic lethality in homologous recombination-deficient cancers by PARP inhibition