Parvalbumin-like EF-hand-containing protein (PVALEF)

Parvalbumin-like EF-hand-containing protein (PVALEF) is a predicted protein in humans, annotated to possess EF-hand calcium-binding domains and to participate in calcium-dependent processes such as skeletal muscle contraction[3][4]. However, experimental evidence of this protein's expression, structure, biological function, or disease relevance is lacking. Its annotation derives primarily from sequence homology to canonical parvalbumins, which are small, cytosolic, acidic proteins in the EF-hand superfamily involved in slow calcium buffering in muscle and regulating calcium signals in neurons[1]. Unlike well-characterized parvalbumins, PVALEF's function, disease role, or clinical significance is unclear, and it may in fact be a misannotated or hypothetical gene product, possibly confused with non-protein-coding RNA (AATK-AS1)[3][4]. Important Notes: - Canonical *parvalbumin* (PV) is well-characterized as a cytosolic calcium-binding protein, especially in muscle and neurons, but "PVALEF" refers to a distinct, poorly characterized paralog or predicted protein[1]. - The gene information for PVALEF contains ambiguity between protein-coding and antisense RNA status[3][4]. - No experimental validation for function, disease association, or pharmacological targeting as of current data. - Use caution when interpreting functional roles or druggability for PVALEF; the canonical parvalbumin family itself is not an approved drug target, but does play key physiological roles in calcium signaling[1]. If you require information on canonical parvalbumin (PV) rather than PVALEF, please clarify, as PV is structurally and functionally well characterized in muscle and neurons[1].

Other names

Parvalbumin-like EF-hand-containing proteinPVALEFAATK-AS1Parvalbumin-like EF-hand-containing protein, AATK antisense RNA 1 (non-protein coding)[3]

None characterized