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PAS domain containing repressor 1 (PASD1)
- Target
- PASD1
- Molecular classification
- Transcription factor, Cancer/testis antigen, PAS domain–containing protein
01
Overview
PAS domain containing repressor 1 is a transcription factor harboring a PAS domain, evolutionarily related to proteins regulating circadian rhythms. Normally restricted to germline tissues, PASD1 becomes aberrantly expressed in various cancers, where it silences circadian clock activity via direct interaction with the CLOCK:BMAL1 complex, and enhances STAT3-mediated transcription by inhibiting dephosphorylation. PASD1 also suppresses apoptosis and advances cell cycle progression, thus promoting oncogenesis. Because of its restricted normal expression and frequent upregulation in solid and hematological malignancies, PASD1 is being actively investigated as a target for DNA vaccines and T-cell–based immunotherapies in cancer
- Other names
- Circadian clock protein PASD1Cancer/testis antigen 63CT63CT64OX-TES-1PAS domain-containing protein 1OXTES1
02
Mechanism of action
For immunotherapies: PASD1 peptides and DNA vaccines elicit cytotoxic T cell responses targeting PASD1-expressing tumor cells
03
Biological functions
Transcriptional regulation (modulates STAT3 activation, represses circadian rhythms)Cell cycle progression (promotes proliferation, inhibits apoptosis, influences G2/M phase arrest)Immune response (recognized as an antigen by cytotoxic T cells)Oncogenesis (promotes tumor growth and survival)
04
Disease associations
Cancer (overexpressed in glioma, lymphoma, multiple myeloma, colorectal cancer)
05
Safety considerations
As a cancer/testis antigen, normal expression is restricted to testicular tissue; cross-reactivity may pose safety concerns regarding fertility or off-target immune effectsUnintended immune activation in healthy tissues is theoretically possible, but not yet reported
06
Interacting drugs
PASD1-targeted DNA vaccines
1 more in the full profile.
07
Biomarkers
PASD1 expression levels (for patient selection and prognosis in cancer, esp. glioma)p53, cyclin B1, caspase-3/9, CDK1 (regulation correlates with PASD1 activity in cell studies)
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