Pasteurella multocida antigens (P. multocida antigens)

Pasteurella multocida antigens are a complex group of molecular structures derived from the Gram-negative bacterium Pasteurella multocida, which causes various severe diseases in livestock and poultry, including fowl cholera and hemorrhagic septicemia (Harper et al., 2006). These antigens primarily include capsular polysaccharides (CPS), which are essential for serogrouping (A, B, D, E, and F) and immune evasion, and lipopolysaccharides (LPS) that contribute to the inflammatory response and endotoxicity (Boyce et al., 2012). Additionally, outer membrane proteins (OMPs) such as OmpA and OmpH are significant targets for the host protective immune response due to their conservation across strains (Hatfaludi et al., 2010). In certain strains, the Pasteurella multocida toxin (PMT) acts as a potent mitogen and virulence factor, making it a critical component for toxoid-based vaccines (Wilson and Ho, 2013). These antigens are utilized in the development of bacterins, subunit vaccines, and recombinant vaccines to stimulate the production of neutralizing antibodies and cellular immunity. The primary therapeutic challenge lies in the antigenic diversity of the species, which often necessitates the use of multivalent vaccines to ensure broad protection against different serotypes (Wilkie et al., 2012).

Other names

Pasteurella multocida surface antigensPasteurella multocida capsular antigensPasteurella multocida outer membrane proteinsPMT antigens

Induction of active immunity through the presentation of bacterial epitopes to B and T lymphocytes, leading to the production of neutralizing antibodies and immunological memory.