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Patatin-like phospholipase domain-containing 3 (PNPLA3)

Target: PNPLA3
Molecular classification: Other (gene)

Overview

PNPLA3 is a gene that encodes a protein involved in lipid metabolism. Variants of this gene, particularly the I148M variant, are associated with an increased risk of developing fatty liver diseases like MASH and NASH by affecting how the body processes fats and repairs liver tissue[1][3][5].

Other names: Adiponutrin

Mechanism of action

Not applicable as PNPLA3 is a gene

Biological functions

Lipid metabolismfat storage regulation

Disease associations

Metabolic dysfunction-associated steatohepatitis (MASH)Nonalcoholic steatohepatitis (NASH)Metabolic syndrome

Biomarkers

Variants of PNPLA3 can serve as genetic biomarkers for risk assessment

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