Patent ductus arteriosus anatomical channel (PDA)

Patent ductus arteriosus is a persistent vascular connection between the pulmonary artery and the aorta that normally closes after birth as fetal circulation changes. Its persistence after birth (PDA) is one of the most common congenital heart defects, particularly in premature infants, and can result in abnormal circulation leading to heart failure, pulmonary hypertension, and other complications. Management includes medical therapy with cyclooxygenase inhibitors (such as indomethacin or ibuprofen lysine) or procedural/surgical closure when necessary. This entry, as stated, is not a canonical molecular drug target (such as a receptor or enzyme) but an anatomical lesion corrected physically or physiologically. If a molecular or receptor target is intended, the name should be revised to reflect a specific protein or biomarker associated with the physiology or pathology of the ductus arteriosus.

Other names

Patent ductus arteriosuspersistent ductus arteriosuspersistent arterial ductPDA

Cyclooxygenase inhibition (reduces prostaglandins to promote closure of the ductus)