Paternally expressed 13 (PEG13)

Paternally expressed 13 (PEG13) is a paternally imprinted long non-coding RNA (lncRNA) gene found in humans (chromosome 8) and mice (chromosome 15)[1][2][3]. It has a key regulatory role in the brain, including modulating neural differentiation, social and sexual behavior, and the expression of other imprinted genes and neuronal function genes[1]. PEG13 also modulates inflammation, notably by suppressing the proinflammatory cytokines HMGB1 and IL-6, and its expression is associated with a reduced inflammatory response in sepsis models, making it a potential therapeutic target for inflammatory diseases[2][4]. In humans, PEG13 is linked to Birk-Barel syndrome, a rare neurological disorder[3]. Loss or dysregulation of PEG13 leads to major behavioral changes, especially related to social interaction, sexual preference, and possibly anxiety and activity levels[1]. PEG13 acts by influencing gene networks rather than encoding a protein, and its exact molecular mechanisms remain under investigation[1][2][4].

Other names

PEG13Paternally expressed 13Peg13

As a non-coding RNA, PEG13 regulates gene expression, including imprinted genes and inflammation-related pathways