Paternally expressed gene 10 protein (PEG10)

Paternally expressed gene 10 protein (PEG10) is a retrotransposon-derived, imprinted gene product widely expressed in mammalian tissues, particularly in the placenta and various cancers. Its protein structure includes domains homologous to retroviral gag and pol, with zinc finger motifs enabling DNA and RNA binding and a protease domain facilitating self-cleavage. PEG10 is essential for placental development and regulates gene expression linked to cell proliferation, migration, and apoptosis. Overexpression is strongly associated with multiple malignancies, poor prognosis, and aggressive tumor growth. Experimentally, PEG10 is a focal point for therapeutic intervention and biomarker development, though targeting safety remains a challenge due to its physiological necessity during development.

Other names

Retrotransposon-derived protein PEG10EDRKIAA1051MAR2MART2RGAG3MEF3-like protein 1HB-1MEF3LSIRH1RTL2Embryonal carcinoma differentiation-regulated proteinMammalian retrotransposon-derived protein 2Sushi-Ichi retrotransposon homolog 1Retrotransposon gag domain-containing protein 3Ty3/Gypsy-like protein

Not fully established for drugs. Curcumin inhibits PEG10 expression (mechanism unclear). Inhibitors of epigenetic modulators (e.g., menin-MLL1 complex inhibitors like MI-503) can downregulate PEG10 transcription via chromatin remodeling. RNA interference (siRNA/shRNA) and gene silencing strategies targeting PEG10 inhibit cancer cell growth and invasion.