Paternally expressed gene 3 (PEG3)

PEG3 (Paternally expressed gene 3) is an imprinted gene expressed only from the paternally inherited allele and encodes a nuclear protein with multiple C2H2 Kruppel-type zinc finger domains[2]. PEG3 acts as a transcription factor, binding DNA in a sequence-specific manner (consensus motif: AGTnnCnnnTGGCT) and regulates the expression of various target genes in pathways involving apoptosis, Wnt signaling, TNF signaling, cell growth, behavior, fat tissue homeostasis, and metabolic activity[2]. PEG3 knockout in mice leads to diverse phenotypes, including altered maternal behaviors, reduced offspring rearing, metabolic abnormalities, and muscle atrophy. It is considered important in placental mammals for developmental and behavioral adaptation[2].

Other names

Peg3paternally expressed gene 3Zinc finger protein PEG3