Pathogen adhesion to intestinal epithelium

“Pathogen adhesion to intestinal epithelium” is the initial step in the colonization and infection by enteric pathogens, involving the interaction of microbial surface molecules (adhesins) with host cell structures (such as glycoproteins and glycolipids on intestinal epithelial cells)[1][2]. This process allows pathogens to establish themselves in the gut, often overcoming host defenses like the mucus layer, antimicrobial peptides, and epithelial turnover[1][2][4]. While critical for the pathogenesis of many infectious diseases, the process itself is not a singular molecular target, but rather a composite biological event implicating various host and microbial factors.

Other names

Pathogen attachment to intestinal epitheliumBacterial adhesion to intestinal epithelium

Prevention of bacterial adhesion (e.g., via probiotics, mucus enhancement, anti-adhesive agents like certain dietary fibers or antibodies) Reinforcement of mucus layer or tight junctions Modulation of microbiota to inhibit pathogenic colonization