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Target intelligence / Profile preview
Pathogen-Associated Molecular Pattern Molecules (PAMPs)
- Target
- PAMPs
- Molecular classification
- Molecular motif, Microbial component
01
Overview
Pathogen-associated molecular patterns (PAMPs) are small, conserved molecular motifs found in groups of microbes but absent from host cells. These molecules are essential for the survival of the microorganisms and serve as universal signatures that allow the innate immune system to distinguish pathogens from self. PAMPs are recognized by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), NOD-like receptors, RIG-I-like receptors, AIM2-like receptors, and C-type lectin receptors, which are present on or within various immune and non-immune cells.
- Other names
- Microbe-Associated Molecular Pattern MoleculesMAMPs
02
Mechanism of action
N/A
03
Biological functions
Innate immune response activationInflammation inductionPattern recognition receptor (PRR) bindingAutophagy initiationAdaptive immunity bridging
04
Disease associations
InfectionInflammatory diseasesSterile inflammation
05
Safety considerations
Excessive inflammationInappropriate immune activationContribution to autoimmune diseases
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