Pathogenic Autoantibody (N/A)

Pathogenic autoantibodies are antibodies produced by the immune system that mistakenly target and bind to the body’s own proteins, cells, or tissues (self-antigens), leading to inflammation, tissue injury, and a range of autoimmune diseases. They are often high-affinity IgG molecules that arise due to a breakdown in self-tolerance mechanisms and can cause disease through various mechanisms, including disrupting normal protein function, forming immune complexes, activating complement, and inducing altered signaling pathways. Their identification is crucial for diagnosis, monitoring disease progression, and developing targeted therapies for autoimmune disorders.

Other names

AutoantibodyDisease-causing autoantibodySelf-reactive antibody

Varies depending on the specific autoantibody and its target. Examples include: B cell depletion, complement inhibition, immunosuppression, neutralization of autoantibody, blockade of receptor signaling.