Pathogenic Autoreactive T Cell

Pathogenic autoreactive T cells are T lymphocytes that mistakenly recognize and react against self-antigens, leading to tissue damage and the development or perpetuation of autoimmune diseases. They arise due to failures in central and peripheral tolerance mechanisms and mediate tissue destruction through direct cytotoxicity or by orchestrating inflammatory responses. These cells are implicated in a wide range of autoimmune disorders and represent a key therapeutic target for modulating disease progression.

Other names

Self-reactive T cellAutoreactive T lymphocyte

Targeting T cell activation, proliferation, or effector function; inducing T cell apoptosis; promoting T cell tolerance; modulating cytokine signaling