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Pathogenic Autoreactive T Cell Receptor

Molecular classification: Receptor, T Cell Receptor (TCR)

Overview

A pathogenic autoreactive T cell receptor is a type of T cell receptor expressed on the surface of T lymphocytes that specifically recognizes self-antigens, leading to an immune response against the body’s own tissues. These receptors are central to the development and progression of autoimmune diseases, as they enable autoreactive T cells to identify and attack self-components, resulting in tissue damage.

Mechanism of action

Depletion or tolerization of autoreactive T cell clones; antigen-specific immunomodulation

Biological functions

Antigen recognitionT cell activationImmune responseCytokine productionT cell proliferationT cell differentiationTissue injury

Disease associations

Autoimmune diseaseSystemic lupus erythematosus (SLE)Type 1 diabetes mellitus (T1D)Multiple sclerosis (MS)Rheumatoid arthritisInflammatory myopathies

Safety considerations

Off-target effects due to cross-reactivityRisk of inducing broad immunosuppressionPotential for exacerbating autoimmunity via epitope spreading

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