Pathogenic bacteria associated with bacterial vaginosis

Pathogenic bacteria associated with bacterial vaginosis refer to a diverse mix of **anaerobic and facultative anaerobic bacteria** that cause a shift from the normal, Lactobacillus-dominated vaginal microbiota to a community dominated by **Gardnerella vaginalis, Atopobium vaginae (now Fannyhesaea vaginae), Mobiluncus species, Prevotella species, Megasphaera, Sneathia, and others**[1][2][3][5]. This dysbiotic bacterial community forms polymicrobial biofilms, raises vaginal pH, and degrades protective mucin, making the vaginal environment more susceptible to inflammation and other infections[1][5][7]. The composition is variable between individuals, but the presence and abundance of Gardnerella and Atopobium are particularly associated with diagnosis and recurrence risk. While some bacterial species within this group are targets for antibiotic therapy, the group as a whole does not constitute a single, well-defined drug target, and management is complicated by recurrence and emerging antibiotic resistance[1][7].

Other names

BV-associated bacteriabacterial vaginosis microbiotaBV microbiotaBV pathogens

Antibacterial (disruption of bacterial cell wall synthesis or function by drugs like metronidazole and clindamycin). Biofilm disruption (emerging therapeutic strategies, not standard drugs).