Pathogenic bacterium in gut lumen

Pathogenic bacteria in the gut lumen are a diverse group of microbial species that reside or invade the gastrointestinal tract and contribute to disease through mechanisms such as infection, toxin production, disruption of mucosal barriers, and induction of host inflammatory responses. They are distinct from commensal, beneficial gut bacteria, and their overgrowth or increased virulence often correlates with dysbiosis—an imbalance in the microbial community. Targeting these bacteria is central to the management of a wide variety of gut-related infectious and inflammatory diseases.

Other names

gut pathogensenteric pathogenspathogenic intestinal bacterium/bacteriaGI pathogenic bacteriainfectious gut bacteria

Direct antimicrobial action (cell wall synthesis inhibition, protein synthesis inhibition, DNA replication inhibition, etc.) Suppression of virulence factor expression Restoration of normal microbiota (competition/exclusion)