Pathogenic bacterium in intestine

Pathogenic bacteria in the intestine refer to a diverse group of bacterial species capable of causing disease in the gastrointestinal tract. These organisms, distinct from commensal gut microbiota, can adhere to, colonize, and damage intestinal mucosa, frequently through the production of toxins or by triggering inflammatory responses. Common intestinal pathogens include species such as Escherichia coli (pathogenic strains), Salmonella enterica, Shigella spp., Campylobacter jejuni, Vibrio cholerae, and Clostridioides difficile. Their presence or overgrowth can result in infections ranging from mild gastritis to severe gastroenteritis and systemic illness. Treatment typically targets the bacteria directly with antibiotics or, more recently, interventions such as bacteriophage therapy and restoration of normal flora with probiotics or fecal microbiota transplantation. The broad categorization of "Pathogenic bacteria in intestine" does not represent a single molecular target but rather a collection of clinically important organisms with varied mechanisms of pathogenicity and interaction with both the host and commensal microbiota[2][3][4][5].

Other names

intestinal pathogensenteric pathogensgut pathogenic bacteriaenteropathogensdiarrheagenic bacteria

Direct killing by antibiotics (cell wall synthesis inhibition, protein synthesis inhibition, DNA replication inhibition); Competitive exclusion by commensal microbiota or probiotics; Lytic destruction by bacteriophages