PAX8 antisense RNA 1 (PAX8-AS1)

PAX8 antisense RNA 1 (PAX8-AS1) is a long non-coding RNA located upstream of the PAX8 gene that regulates PAX8 expression and functions in cell proliferation and apoptosis. PAX8-AS1 is downregulated in papillary thyroid carcinoma tissues, where overexpression impedes cellular proliferation and enhances apoptosis[1][2]. In contrast, PAX8-AS1 is overexpressed in acute myeloid leukemia, contributing to chemoresistance by inhibiting apoptosis and promoting cell viability through the miR-378g/ERBB2 axis[3]. PAX8-AS1 is increasingly recognized as a functional regulator and therapeutic target due to its role in cancer progression and drug resistance, with its expression serving as a prognostic indicator in various malignancies[1][2][3]. Overall, PAX8-AS1 is a functionally implicated lncRNA in several cancers, acting primarily through the modulation of proliferation, apoptosis, and drug resistance, and its manipulation holds promise for targeted cancer therapy[1][2][3].

Other names

PAX8-AS1PAX8 antisense RNA 1

Drugs targeting PAX8-AS1 would typically act by altering its expression (either silencing or overexpressing), thereby affecting cellular apoptosis and proliferation. Chemoresistance in AML due to PAX8-AS1 involves the miR-378g/ERBB2 axis.