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PCOLCE antisense RNA 1 (non-protein coding) (PCOLCE-AS1)
- Target
- PCOLCE-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding RNA
01
Overview
PCOLCE antisense RNA 1 (PCOLCE-AS1) is a long non-coding RNA gene located on chromosome 7q22.1 and does not code for a protein[3][5]. It is transcribed antisense to the PCOLCE protein-coding gene and is affiliated with the lncRNA class[5]. Recent research suggests that PCOLCE-AS1 may act as a biomarker of immune-depleted tumor microenvironments in ovarian cancer, with higher expression found in immune-depleted tumor tissues compared to immune-enriched ones—implying a role in regulating local immune states[4]. Functional annotation indicates that PCOLCE-AS1 undergoes RNA A-to-I editing, which can alter its interaction with microRNAs and perhaps influence RNA stability and gene regulation networks[3]. However, it is not currently considered a direct therapeutic target such as a receptor, enzyme, or transporter, and no known drugs are directed against it. Research on its mechanistic role and utility in disease remains ongoing.
- Other names
- PCOLCE-AS1PCOLCE antisense RNA 1PCOLCE Antisense RNA 1 (non-protein coding)
02
Biological functions
Potential biomarker for tumor immune environment in ovarian cancer[4]Implicated in regulation of gene expression through antisense mechanisms[3]May influence mRNA stability and microRNA binding via RNA editing[3]
03
Disease associations
Cancer (studied in ovarian cancer tumor immunity)[4]Possibly other roles related to immune cell infiltration, but further evidence required
04
Biomarkers
May serve as an indicator of immune-depleted ovarian cancer tumors[4]
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