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PCSK6 antisense RNA 1 (PCSK6-AS1)

Target: PCSK6-AS1
Molecular classification: Long non-coding RNA (lncRNA), Other (not receptor, enzyme, transporter, etc.; regulatory non-coding RNA)

Overview

PCSK6 antisense RNA 1 (PCSK6-AS1) is a long non-coding RNA transcribed from a bidirectional promoter in the PCSK6 gene locus. It spans intronic regions and is alternatively spliced. PCSK6-AS1 and related antisense RNAs may regulate PCSK6 expression and contribute to fine-tuning tissue-specific gene expression, especially in the nervous system. The locus is functionally important for handedness and has potential links to neurodevelopmental disorders; however, the biological activity and disease relevance of PCSK6-AS1 itself are not fully characterized, and it is not considered a canonical therapeutic target.

Other names: PCSK6-AS1PCSK6-AS2

Biological functions

Regulation of gene expressionPotential contribution to neurodevelopment or neuronal differentiation

Disease associations

Neurodevelopmental disordersHandedness

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