PCYT1B antisense RNA 1 (PCYT1B-AS1)

**PCYT1B antisense RNA 1 (PCYT1B-AS1)** is a long non-coding RNA (lncRNA) gene located on chromosome X (chrX:24650073-24658237, GRCh38), transcribed from the DNA strand opposite the protein-coding gene PCYT1B[3][7][9]. This lncRNA is categorized as an antisense RNA because it overlaps with the PCYT1B gene but does not code for a protein[6]. PCYT1B-AS1 has been described in gene annotation resources as important for glial cell lipid metabolism and myelination, suggesting a regulatory role in nervous system cell function[9]. There is currently no published evidence it is directly associated with major diseases, therapeutic drug targeting, or use as a clinical biomarker. PCYT1B-AS1 is not a protein target (such as a receptor, enzyme, or transporter) and is not considered a classic drug target. Its molecular mechanism is likely via regulation of gene expression of nearby genes, particularly PCYT1B, possibly modulating phosphatidylcholine biosynthetic processes in the central nervous system.

Other names

PCYT1B-AS1PCYT1B antisense RNA 1 (non-protein coding)