PDE11A antisense RNA 1 (PDE11A-AS1)

PDE11A antisense RNA 1 (PDE11A-AS1) is a naturally occurring long non-coding RNA transcribed in antisense orientation to the PDE11A gene. Antisense RNAs typically regulate the expression of their overlapping coding genes through mechanisms such as transcriptional interference, RNA duplex formation, and recruitment of chromatin-modifying proteins[2][4]. PDE11A-AS1’s specific biological or disease functions in humans are not well defined, but it is classified as a regulatory RNA involved in modulating gene expression rather than as a direct drug target or member of major protein families such as receptors or enzymes. Antisense RNAs like PDE11A-AS1 are recognized for their roles in fine-tuning gene expression and may have tissue- or context-specific regulatory effects[2][4]. Note: There is extensive literature on the protein-coding gene PDE11A, phosphodiesterase 11A, which is a cyclic nucleotide phosphodiesterase enzyme[1][3][5]. However, PDE11A-AS1 is distinct from the PDE11A protein: PDE11A-AS1 is an antisense lncRNA and not a druggable molecular target in the classical sense. There is no evidence suggesting PDE11A-AS1 is itself a therapeutic target or currently associated with drug interactions, known disease mutations, or biomarker roles. For the canonical name, abbreviation, and classifications, conventions from nomenclature databases and recent reviews on antisense RNA function have been used[2][4].

Other names

PDE11A-AS1

Endogenous modulation of sense gene mRNA (e.g., PDE11A) expression by influencing transcription, stability, or processing of mRNA[2][4] May act via transcriptional interference or chromatin remodeling[2]