PDE2A antisense RNA 1 (PDE2A-AS1)

PDE2A antisense RNA 1 (PDE2A-AS1) is a long non-coding RNA gene situated antisense to the *PDE2A* gene locus[5]. Unlike the protein-coding PDE2A, this gene produces a non-coding RNA that likely regulates the expression of PDE2A or nearby genes at the RNA level. There is no evidence to date that PDE2A-AS1 encodes a protein or acts as a direct therapeutic target, receptor, enzyme, transporter, or similar druggable entity. Its principal characterized function is presumed regulatory, involving modulation of gene expression, but detailed mechanistic or disease associations are not established in the core biomedical databases[5]. *PDE2A-AS1* is distinct from the protein-coding phosphodiesterase 2A (PDE2A) gene; the latter encodes an important cyclic nucleotide phosphodiesterase, while *PDE2A-AS1* is a non-coding RNA[5]. There is no reported drug or small molecule that directly targets PDE2A-AS1, nor are there established safety concerns or biomarker uses for this lncRNA. If you require details on the protein-coding *PDE2A* target rather than its antisense non-coding RNA, please clarify, as the biological roles and druggability profiles are fundamentally different.

Other names

PDE2A-AS1 RNAAntisense non-coding RNA in PDE2A locus