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PDZ and LIM domain protein 1 (PDLIM1)
- Target
- PDLIM1
- Molecular classification
- Adapter/scaffold protein, Actin-associated protein, Other
01
Overview
PDZ and LIM domain protein 1 (PDLIM1) is a cytoplasmic protein that acts as an adapter/scaffold associated with the actin cytoskeleton, containing an N-terminal PDZ domain and a C-terminal LIM domain[3][2][1]. It organizes multi-protein complexes by linking actin and α-actinin to various signaling proteins and plays key roles in regulating stress fibers, cell polarity, and cell migration in fibroblasts[3][2][1]. Dysregulation or misexpression of PDLIM1 and related family members has been implicated in cancer progression, cardiovascular diseases, and defects in cell adhesion and migration[2][3]. PDLIM1 has also been suggested to modulate signal transduction by sequestering nuclear factors in the cytoplasm[2].
- Other names
- CLP-36ElfinCLIM1PDZ and LIM domain 1
02
Biological functions
Cytoskeleton organizationSignal transductionCell migrationCell polarityAdapter/scaffold for protein complex assembly
03
Disease associations
CancerCardiovascular diseaseOther
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