PDZ and LIM domain protein 7 (PDLIM7)

**PDZ and LIM domain protein 7 (PDLIM7)** is a member of the PDZ-LIM protein family, characterized by an N-terminal PDZ domain and three C-terminal LIM domains[1][3][4]. This protein serves as an *adaptor or scaffold*, organizing signaling proteins at the actin cytoskeleton and facilitating specific protein-protein interactions. It plays crucial roles in actin filament organization in muscle and non-muscle tissue, regulates transcription factor localization, and participates in both direct and endochondral bone formation, including during fracture repair[4][1]. PDLIM7 also modulates inflammatory responses by acting as an E3 ubiquitin ligase, synergistically facilitating nuclear degradation of NF-κB p65 in cooperation with PDLIM2 and p62/Sqstm1, thus suppressing proinflammatory cytokine production[2]. While it is not an established drug target, its involvement in essential cellular scaffolding, gene regulation, and negative regulation of inflammatory signaling underlies its significance in development, tissue repair, and immune homeostasis[1][2][4][5].

Other names

LMP1LMP3ENIGMALim mineralization protein 3Protein enigmaLIM domain proteinLMPLim mineralization protein1110003B01RikPDZ and LIM domain protein 7

Not applicable; PDLIM7 is not a primary drug target, but as a negative regulator, loss or altered function could impact inflammatory or differentiation signaling[2].