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Target intelligence / Profile preview
T-cell-originated protein kinase (TOPK)
- Target
- TOPK
- Molecular classification
- Enzyme, Serine/threonine kinase, MAPKK family
01
Overview
T-cell-originated protein kinase (TOPK), also known as PBK, is a serine/threonine kinase belonging to the MAPKK family. It plays a critical role in cell division, particularly in regulating cytokinesis during mitosis. TOPK is highly expressed in various tumor tissues and is linked to enhanced proliferation, increased migration/invasion, tumor metastasis, and drug resistance. It serves as a prognostic biomarker and a therapeutic target for multiple cancers. Inhibitors like OTS514 have shown promise in suppressing cancer cell growth and enhancing sensitivity to chemotherapy.
- Other names
- PBKPDZ-binding kinaseT-LAK cell-originated protein kinaseLymphokine-activated killer T-cell-originated protein kinase
02
Mechanism of action
Inhibition of TOPK suppresses proliferation/migration of cancer cells, promotes apoptosis, and enhances sensitivity to chemotherapeutics.
03
Biological functions
Cell cycleMitotic regulationCell proliferationCytokinesisLymphoid cell activationSpermatogenesis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to kinase similarityToxicity associated with cell cycle inhibition
06
Interacting drugs
OTS514
2 more in the full profile.
07
Biomarkers
TOPK expression level in tumor tissue
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