PDZ domain-containing RING finger protein 4 (PDZRN4)

PDZ domain-containing RING finger protein 4 (PDZRN4) is a human protein encoded by the PDZRN4 gene. It belongs to the PDZ domain-containing RING finger protein family, specifically functioning as an E3 ubiquitin ligase due to the presence of a RING finger domain[3][5]. PDZRN4 is implicated in metal ion binding and mediates protein–protein interactions, likely involved in regulating signaling pathways and cell fate by scaffolding complexes via PDZ domains[3][5]. Evidence suggests a putative tumor suppressor role in certain cancers such as hepatocellular carcinoma by exhibiting anti-proliferative effects and a similar protein family member is implicated in synovial sarcoma proliferation[2][8]. However, PDZRN4 is not a widely recognized drug target, and no specific therapies are directed against it or use it as a clinical biomarker. The protein exhibits tissue expression in various organs, including smooth muscle, and may play broader roles in development or signaling, consistent with the functions of related PDZ domain/RING finger proteins[7].

Other names

LNX4SAMCAP3LSEMCAP3LDKFZp434B0417FLJ33777IMAGE5767589Ligand of Numb protein X 4SEMACAP3-like proteinsimilar to semaF cytoplasmic domain associated protein 3LU1