PDZK1 interacting protein 1 (PDZK1IP1)

PDZK1 interacting protein 1 (PDZK1IP1, also called MAP17, DD96, SPAP) is a small, 17 kDa nonglycosylated protein located at the plasma membrane and Golgi apparatus, principally found in epithelial cells of the kidney but strongly overexpressed in various carcinomas (breast, kidney, colon, lung). It functions as a cargo/adaptor protein with a PDZ-binding domain, interacting with PDZK1 and facilitating the membrane targeting of specific sodium-glucose cotransporters (notably SGLT2/SLC5A2). PDZK1IP1 activates the Notch signaling pathway (via NUMB), increasing stemness and promoting epithelial-mesenchymal transition, tumor progression, and metastatic potential. MAP17 influences the immune microenvironment via molecular networks involving the inflammasome and pro-inflammatory cytokines. While its physiological role is still being investigated, MAP17 expression is a robust marker for aggressive cancers, and its activity is implicated in oncogenic transformation and immune processes, making it of significant interest as a cancer biomarker and a candidate for targeted research.

Other names

MAP17DD96SPAP17 kDa membrane-associated proteinProtein DD96epithelial protein up-regulated in carcinomamembrane associated protein 17membrane-associated protein 17

Indirect modulation through inhibition or activation of Notch pathway, possibly by targeting the cargo function or its protein interactions (e.g., disrupting PDZK1IP1-NUMB interaction) Not established for direct pharmacologic targeting