Peach non-specific lipid-transfer protein 1 (Pru p 3) (Pru p 3)

Peach non-specific lipid-transfer protein 1, commonly known as Pru p 3, is the primary allergen responsible for severe peach allergies (UniProt P81402). It belongs to the nsLTP family, characterized by a compact structure that provides exceptional resistance to heat and gastrointestinal proteolysis (PubMed: 22404443). This stability allows the protein to reach the intestinal mucosa intact, where it is captured by antigen-presenting cells like dendritic cells, a process partially mediated by the mannose receptor (PubMed: 23504429). Once internalized, Pru p 3 is processed into immunogenic peptides and presented on MHC class II molecules to CD4+ T-cells (PubMed: 20545700). This interaction typically triggers a Th2-polarized immune response, leading to IgE production and potential anaphylaxis (PubMed: 21834845). Therapeutic interventions, such as allergen-specific immunotherapy, target these pathways to induce immunological tolerance (PubMed: 24635444). Understanding the specific mechanisms of Pru p 3 uptake is crucial for developing safer vaccines that favor regulatory T-cell induction over allergic sensitization (PubMed: 25526335).

Other names

Pru p 3Peach nsLTPNon-specific lipid-transfer protein 1Prunus persica allergen 3LTP1

Induction of immune tolerance by modulating the antigen-presenting cell and T-cell interaction to shift the immune response from a Th2 to a Th1/Treg profile (PubMed: 24635444).