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Peach Protein Allergens

Molecular classification: PR-10 protein, Non-specific Lipid Transfer Protein (nsLTP), Profilin, Allergen

Overview

Peach protein allergens are a group of proteins found in peaches (Prunus persica) that can trigger allergic reactions in sensitized individuals. The major allergens include Pru p 1 (PR-10 protein), Pru p 3 (nsLTP), and Pru p 4 (profilin). These allergens are responsible for a range of clinical symptoms, from mild oral allergy syndrome (OAS) to severe systemic reactions such as anaphylaxis. Pru p 3, an nsLTP, is considered the major peach allergen due to its heat stability and association with severe reactions.

Other names: Prunus persica allergensPeach allergy proteinsPru p 1Pru p 3Pru p 4

Biological functions

AllergenicityImmune responseLipid binding (nsLTP)Actin binding (profilin)Pathogenesis-related (PR-10)

Disease associations

Food allergyOral Allergy Syndrome (OAS)AnaphylaxisPollen-food allergy syndrome (PFAS)

Safety considerations

Allergic reactions ranging from mild OAS to severe anaphylaxisCross-reactivity with other fruits, vegetables, and pollenPotential for severe reactions even to cooked/processed peaches (Pru p 3)

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