PEAK family member 3 (PEAK3)

PEAK family member 3 (PEAK3) is a pseudokinase and molecular scaffold protein, part of the PEAK family (NKF3) along with PEAK1 and PEAK2/Pragmin[1][4][5]. PEAK3 is structurally similar to other family members but is unique in its domain features and binding interfaces, including a fully resolved activation loop and αC helix. It acts as a signaling hub downstream of growth factor stimulation and is dynamically regulated by phosphorylation, especially through interactions with 14-3-3 proteins, CrkII, and other scaffold/adaptor proteins. PEAK3 dimerizes through a conserved SHED domain, forming homo- and heterodimers. Functionally, PEAK3 controls cell motility, migration, and morphology, and its overexpression has been shown to promote invasive, oncogenic behaviors in several cancer cell models. Recent cryo-EM studies highlight its complex with regulatory proteins such as 14-3-3, impacting localization and interactome diversity. PEAK3 is increasingly viewed as an important disease target, particularly in oncology, though no therapeutic interventions have yet been reported[1][3][4][5].

Other names

C19orf35Chromosome 19 open reading frame 35FLJ45778Protein PEAK3PEAK3