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Pecanex-like protein 1 (PCNX1)

Target: PCNX1
Molecular classification: Transmembrane protein, Other (not classified as receptor, channel, enzyme, transporter, or transcription factor; its main feature is conserved transmembrane domains)

Overview

Pecanex-like protein 1 (PCNX1) is a conserved transmembrane protein in humans, similar to the Drosophila pecanex protein, which plays a role in developmental processes through the Notch signaling pathway[2][6]. While its precise function in humans remains unclear, PCNX1 has been implicated in certain cancers through gene fusion events and is associated with small intestine neuroendocrine neoplasm[1][2]. No direct therapeutic targeting, interacting drugs, or known safety concerns are currently documented for PCNX1[2][6][7].

Other names: PCNX1PCNXPCNXL1KIAA0805KIAA0995Pecanex homolog 1Pecanex-like protein 1Pecanex

Biological functions

Developmental pathways (homologous fly protein is part of Notch signaling)Possibly cell signaling or differentiation (inference based on homology to Drosophila pecanex in Notch pathway)

Disease associations

Cancer (specifically, gene fusion events with PCNX1 have been observed in human cancers, e.g., lung adenocarcinoma)Small intestine neuroendocrine neoplasm (association noted by GeneCards)

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