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Target intelligence / Profile preview
Pecanex-like protein 2 (PCNX2)
- Target
- PCNX2
- Molecular classification
- Other (not classified as a receptor, enzyme, ion channel, transporter, or transcription factor in current major databases; classified as a protein-coding gene)
01
Overview
Pecanex-like protein 2 (PCNX2) is a protein-coding gene found in humans, characterized by the presence of coding mononucleotide repeats and associations with tumors exhibiting high microsatellite instability (MSI-H), especially colorectal cancer. It may act as a competitive endogenous RNA regulating the oncogenic protein Skp2, influencing cell cycle progression, proliferation, and apoptosis in non-small cell lung cancer cell models. Other aliases include KIAA0435, PCNXL2, and Pecanex homolog 2. There is no evidence for direct clinical targeting as a receptor, enzyme, or other classic drug target class. There are no known small molecule or biologic drugs that directly interact with PCNX2. Its mutation or dysregulation may contribute to tumorigenesis in certain cancer types, but it has not been validated as a clinical biomarker or therapy target to date.
- Other names
- Pecanex 2PCNX2KIAA0435PCNXL2FLJ11383Pecanex homolog protein 2Pecanex homolog 2pecanex-like protein 2
02
Mechanism of action
Not established
03
Biological functions
May play a role in tumorigenesis, especially in colorectal carcinomas with high microsatellite instability (MSI-H)May act as a competitive endogenous RNA (ceRNA), positively regulating S-phase kinase-associated protein 2 (Skp2) expression, promoting cell growth, cell cycle progression, and inhibiting apoptosis in non-small cell lung cancer models
04
Disease associations
Cancer: Colorectal carcinoma with high microsatellite instability (MSI-H)Cancer: Non-small cell lung cancer (shown in cell models)Genetic syndromes: Autosomal Dominant Nonsyndromic Deafness 78 (association noted, but not causal)Genetic syndromes: Latent Syphilis (association noted, not causal)
05
Safety considerations
Not established
06
Interacting drugs
None known
07
Biomarkers
None established
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