PEDS1-UBE2V1 readthrough transcript (PEDS1-UBE2V1)

The **PEDS1-UBE2V1 readthrough transcript** is a rare, naturally occurring mRNA produced by the read-through transcription of the neighboring TMEM189 (formerly PEDS1) and UBE2V1 genes. This transcript encodes a fusion protein combining regions from both parent genes, specifically harboring UEV1 B domains typical of ubiquitin-conjugating E2 enzyme variant proteins. The protein is localized to the cytoplasm but lacks a defined biological function. The clinical and physiological significance of the readthrough transcript and its fusion protein product remain undetermined, and it is not currently known to act as a discrete therapeutic target, receptor, enzyme, transporter, or recognized disease gene. The individual genes, PEDS1 and UBE2V1, have distinct biological roles and disease associations, but these have not been described for the fusion protein itself[2][3][4]. **Note:** This entry is not a canonical therapeutic target, but a gene fusion or read-through product with unclear biological and therapeutic significance. If you are seeking therapeutic information (e.g., druggability, mechanism, or interaction with drugs), refer instead to the parent genes—TMEM189 (PEDS1) or UBE2V1—themselves.

Other names

Kua-UEVCROC-1BCROC1BKUA-UEVTMEM189-UBE2V1TMEM189-UBE2V1 fusion proteinTMEM189-UBE2V1 readthrough transcripttransmembrane protein 189-ubiquitin-conjugating enzyme E2 variant 1 read-through