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Target intelligence / Profile preview
Pellino E3 ubiquitin protein ligase 1 (PELI1)
- Target
- PELI1
- Molecular classification
- Enzyme, E3 ubiquitin ligase, RING-type E3 ubiquitin ligase
01
Overview
PELI1 is a highly conserved E3 ubiquitin ligase that catalyzes the covalent attachment of ubiquitin to substrate proteins. It plays a central role in several signaling pathways, particularly those involved in immune and inflammatory responses. PELI1 mediates both Lys63- and Lys48-linked polyubiquitination, influencing protein stability and signaling outcomes. It is a potential therapeutic target for modulating inflammation or enhancing antitumor immunity through metabolic reprogramming control in immune cells.
- Other names
- Pellino-1PRISM
02
Mechanism of action
E3 ubiquitin ligase activity, mediating ubiquitination of target proteins.
03
Biological functions
UbiquitinationSignal transductionImmune responseInflammatory responseDNA damage responseRegulation of necroptosisRegulation of mTORC1 signalingCytokine production
04
Disease associations
Autoimmune diseasesInflammationCancer
05
Safety considerations
Aberrant immune cell activationPotential for autoimmune symptoms when deficientComplex role in inflammatory pathways requires careful targeting to avoid unintended consequences
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