Target intelligence / Profile preview

Pendrin (N/A)

Target: N/A
Molecular classification: Transporter, Anion exchanger

Overview

Pendrin is an anion exchange protein encoded by the SLC26A4 gene. It functions as a transporter of negatively charged ions such as chloride, iodide, and bicarbonate across cell membranes. Pendrin is crucial for maintaining ion homeostasis in several tissues, including the inner ear, thyroid gland, and kidney. Mutations in SLC26A4 cause Pendred syndrome, characterized by sensorineural hearing loss and goiter.

Other names: SLC26A4

Mechanism of action

N/A

Biological functions

Chloride/bicarbonate exchangeChloride/iodide exchangeIon homeostasisAcid-base balance

Disease associations

Pendred syndromeSensorineural hearing lossGoiterHypothyroidism

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